Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Many of us assume that stopping drinking is simply about self-control. But if you've ever tried to cut down—or stop entirely—you'll know it's not that simple. It often feels like you're fighting your own brain. And in many ways, that’s exactly what’s happening.
If you've been searching for a solution to problem drinking, you've likely come across The Sinclair Method (TSM). Unlike traditional recovery approaches that focus on abstinence, TSM helps people gradually reduce their alcohol consumption with the aid of Naltrexone—a prescription medication that blocks the brain’s reward response to alcohol.